Article

A benchmark of the somatic mutation landscape using single-cell and single-molecule whole-genome sequencing

2025-09-04

Abstract excerpt

Accurate detection of somatic mutations in noncancerous cells is critical for studying somatic mosaicism, a process implicated in aging and multiple chronic diseases. However, single-cell and single-molecule DNA sequencing platforms differ in their error profiles, coverage biases, and sensitivity to specific mutation types, complicating cross-platform comparisons. Here, we present in vitro and in silico benchmar...

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Literature Corpus work: 39c0c8e4-9517-533f-8734-6c54ffd3c708
DOI: 10.1101/2025.08.31.673349

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