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MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state

2023-02-08

Abstract excerpt

Genome-wide association studies (GWAS) have identified many modifiers of Alzheimer disease (AD) risk enriched in microglia. Two of these modifiers are common variants in the MS4A locus (rs1582763: protective and rs6591561: risk) and serve as major regulators of CSF sTREM2 levels. To understand their functional impact on AD, we used single nucleus transcriptomics to profile brains from carriers of these variants....

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Identifiers and source

Literature Corpus work
a32c3519-9962-5d12-82d8-7d4ffdb807d9
DOI
10.1101/2023.02.06.23285545
Open publication

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MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia stateDOI 10.1101/2023.02.06.23285545
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