Article

<i>Ms4a4a</i> loss reprograms amyloid-associated microglia and limits dense-core plaque-associated tau spreading

2026-07-27

Abstract excerpt

<h4>INTRODUCTION</h4> Microglia regulate amyloid plaque-associated microenvironments that contribute to downstream tau pathology in Alzheimer’s disease (AD). Variants within the MS4A locus are strongly associated with AD risk and resilience and are linked to microglial biology; however, the functional role of MS4A4A in plaque-associated tau pathology remains poorly understood. <h4>METHODS</h4> Single-nucleus...

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Literature Corpus work: 255e09a4-1391-5678-a925-8d22bb830e3f
DOI: 10.64898/2026.07.22.740167

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