Article

Lipid peroxidation induced ApoE receptor-ligand disruption as a unifying hypothesis underlying sporadic Alzheimer’s disease in humans

2021-07-06

Abstract excerpt

<h4>Structured Abstract</h4> <h4>Background</h4> Sporadic Alzheimer’s disease (sAD) lacks a unifying hypothesis that can account for the lipid peroxidation observed early in the disease, enrichment of ApoE in the central core of neuritic plaques, the hallmark plaques and tangles, and the selective vulnerability of entorhinal-hippocampal structures. <h4>Objective</h4> We hypothesized that (1) high expression of Apo...

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Literature Corpus work: d465caf5-198b-566d-81c6-ff4e212bc2fd
DOI: 10.1101/2021.07.05.21259649

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