Article

Rescue of In Vitro Models of CSF1R-Related Adult-Onset Leukodystrophy by Iluzanebart: Mechanisms and Therapeutic Implications of TREM2 Agonism

2024-12-12

Abstract excerpt

<title>Abstract</title> Microglia dysfunction is implicated in several neurodegenerative disorders, including a rare microgliopathy; CSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (CSF1R-ALSP). CSF1R-ALSP is caused by heterozygous loss-of-function mutations in the colony stimulating factor 1 receptor (CSF1R) gene, which encodes a receptor required for the differentiation...

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Literature Corpus work: 6acf5394-ca3f-521a-a538-274171af5ea6
DOI: 10.21203/rs.3.rs-5181288/v2

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