Article

SPICE: A Robust Computational Framework for Identifying Copy Number Variations in Spatial Transcriptomics

2026-07-04

Abstract excerpt

Copy number variation (CNV), which alters the number of genomic segments, is a major driver of intratumor heterogeneity, characterized by spatially organized and genetically distinct cell populations. Recent advances in spatially resolved transcriptomic (SRT) technologies, which profile gene expression across thousands of spatially indexed tissue locations, offer a powerful opportunity to reconstruct the CNV archi...

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Literature Corpus work: a2dd81c8-02c2-506f-a8f3-19594d1c31c0
DOI: 10.64898/2026.06.30.735508

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