Article

Resolving single-cell copy number profiling for large datasets

2022-02-10

Abstract excerpt

<h4>ABSTRACT</h4> The advances of single-cell DNA sequencing (scDNA-seq) enable us to characterize the genetic heterogeneity of cancer cells. However, the high noise and low coverage of scDNA-seq impede the estimation of copy number variations (CNVs). In addition, existing tools suffer from intensive execution time and often fail on large datasets. Here, we propose SeCNV, a novel method that leverages structural...

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Literature Corpus work: 90b6cf25-71a3-5eb0-98bb-476207405925
DOI: 10.1101/2022.02.09.479672

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