Article

The spatial landscape of clonal somatic mutations in benign and malignant tissue

2021-07-12

Abstract excerpt

Defining the transition from benign to malignant tissue is fundamental to improve early diagnosis of cancer. Here, we provide an unsupervised approach to study spatial genome integrity in situ to gain molecular insight into clonal relationships. We employed spatially resolved transcriptomics to infer spatial copy number variations in >120 000 regions across multiple organs, in benign and malignant tissues. We demo...

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Literature Corpus work: 204cffaf-8fb2-5e32-a473-bf07e0c0f6e3
DOI: 10.1101/2021.07.12.452018

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