Article

Inferring copy number variation from gene expression data: methods, comparisons, and applications to oncology

2021-10-19

Abstract excerpt

<h4>ABSTRACT</h4> Copy number variations (CNVs) are genomic events where the number of copies of a particular gene varies from cell to cell. Cancer cells are associated with somatic CNV changes resulting in gene amplifications and gene deletions. However, short of single-cell whole-genome sequencing, it is difficult to detect and quantify CNV events in single cells. In contrast, the rapid development of single-ce...

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Literature Corpus work: c74d881e-6317-5156-8df0-865fd290372f
DOI: 10.1101/2021.10.18.463991

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