Article

Hybrid Ornstein–Uhlenbeck–Branching Modeling of Pediatric Leukemia Evolution: A Computational Extension and Cohort-Level Application

2025-11-07

Abstract excerpt

Pediatric cancers evolve under developmental constraints that limit mutational diversity yet preserve adaptive potential. A computational extension of the Hybrid Ornstein–Uhlenbeck (OU)–Branching framework was developed to model clonal diversification and phenotypic stabilization in pediatric leukemia. The OU component captures mean-reverting dynamics representing developmental homeostasis, while the branching com...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2d76b39-34ff-5e0e-a40b-0899553893ac
DOI: 10.1101/2025.11.07.686044

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hybrid Ornstein–Uhlenbeck–Branching Modeling of Pediatric Leukemia Evolution: A Computational Extension and Cohort-Level ApplicationDOI 10.1101/2025.11.07.686044Read

Single-cell immune ecotypes shape microenvironment-modulated evolutionary dynamics in pediatric leukemiaSemantic proximity Read

Extensive Clonal Branching Shapes the Evolutionary History of High-Risk Pediatric CancersSemantic proximity Read

Mutational dynamics of early and late relapsed childhood ALL: rapid clonal expansion and long-term dormancy.Semantic proximity Read

Interpretable spatial ecological dynamics reveal ecological retention escape and amplification in pediatric leukemiaSemantic proximity Read

The eco-evolutionary dynamics of acute myeloid leukemia: From clonal games to clinical intervention.Semantic proximity Read

Genotype- and Age-Specific Relapse Dynamics in Childhood Acute Lymphoblastic Leukemia: A Longitudinal Mechanistic StudySemantic proximity Read

Discovery of Dynamic Models for AML Disease Progression from Longitudinal Multi-Modal Clinical Data Using Explainable Machine LearningSemantic proximity Read

Transient Differentiation-State Plasticity Occurs during Acute Lymphoblastic Leukemia Initiation.Semantic proximity Read

Clonal evolution of acute leukemia genomes.Semantic proximity Read

Lineage-aware stochastic modeling reveals gene-expression dynamics in development and diseaseSemantic proximity Read

BESTish: A Diffusion-Approximation Framework for Inferring Selection and Mutation in Clonal HematopoiesisSemantic proximity Read

Evolutionary dynamics of 1,976 lymphoid malignancies predict clinical outcomeSemantic proximity Read