Article

Single-cell immune ecotypes shape microenvironment-modulated evolutionary dynamics in pediatric leukemia

2026-03-03

Abstract excerpt

<title>Abstract</title> <p>Tumor evolution is shaped not only by intrinsic genetic alterations but also by selective pressures imposed by the tumor microenvironment (TME). Although single-cell profiling increasingly resolves ecological heterogeneity, quantitative evolutionary models that explicitly incorporate microenvironmental structure remain limited. Here, we introduce a TME-modulated Ornstein–Uhlenbeck (OU)...

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Literature Corpus work: 6a9e9ad9-9f42-5bcd-82be-b87c13a19c03
DOI: 10.21203/rs.3.rs-9012769/v1

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