Article

Genetic drivers of repeat expansion disorders localize to 3-D chromatin domain boundaries

2017-09-20

Abstract excerpt

More than 25 inherited neurological disorders are caused by the unstable expansion of repetitive DNA sequences termed short tandem repeats (STRs). A fundamental unresolved question is why specific STRs are susceptible to unstable expansion leading to severe pathology, whereas tens of thousands of normal-length repeat tracts across the human genome are relatively stable. Here, we unexpectedly discover that nearly a...

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Identifiers and source

Literature Corpus work: 9f55d4b4-09fc-5cf7-85b4-37b248953de8
DOI: 10.1101/191213

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