Article

Modeling the evolutionary architectures of human enhancer sequences reveals distinct origins, functions, and associations with human-trait variation

2020-08-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Motivation</h4> Despite the importance of gene regulatory enhancers in human biology and evolution, we lack a comprehensive evolutionary model of enhancer sequence architecture and function. This substantially limits our understanding of the genetic basis for divergence between species and our ability to interpret the effects of non-coding variants on human traits. <h4>Results</h4> To expl...

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Literature Corpus work: 25261202-06c7-5e0d-8d36-2bc6eabbf3b8
DOI: 10.1101/2020.08.03.235051

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