Article

Sex and BDNF Val66Met Polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice

2022-07-31

Abstract excerpt

Females show greater benefits of exercise on cognition in both humans and rodents, which may be related to brain-derived neurotrophic factor (BDNF). A single nucleotide polymorphism (SNP), the Val66Met polymorphism, within the human BDNF gene, causes impaired activity-dependent secretion of neuronal BDNF and impairments to some forms of memory. We evaluated whether sex and BDNF genotype (Val66Met polymorphism (Me...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2a0c6bf-513e-5b93-82f2-0e05a5365de5
DOI: 10.1101/2022.07.29.502070

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sex and BDNF Val66Met Polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged miceDOI 10.1101/2022.07.29.502070Read

Sex and BDNF Val66Met polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice.Semantic proximity Read

Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice.Semantic proximity Read

Impact of the BDNF Val66Met polymorphism on cognition: implications for behavioral genetics.Semantic proximity Read

Brain-Derived neurotrophic factor Val66met is associated with sex-specific impairment of cognitive flexibility under stress: A reversal learning search strategy analysis in a rat model.Semantic proximity Read

Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior.Semantic proximity Read

Impact of genetic variant BDNF (Val66Met) on brain structure and function.Semantic proximity Read

Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory.Semantic proximity Read

Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism contributes to developmental and estrous stage-specific expression of anxiety-like behavior in female mice.Semantic proximity Read

BDNF variant linked to anxiety-related behaviors.Semantic proximity Read

Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination.Semantic proximity Read

Impaired fear memory in a rat model of the brain-derived neurotrophic factor Val66Met polymorphism is reversed by chronic exercise.Semantic proximity Read

Exercise-Mediated Neurogenesis in the Hippocampus via BDNFSemantic proximity Read