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Article

Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Mar 2008

Bath Kevin G, Mandairon Nathalie, Jing Deqiang, Rajagopal Rithwick, Kapoor Ruchi, Chen Zhe-Yu, Khan Tanvir, Proenca Catia C, Kraemer Rosemary, Cleland Thomas A, Hempstead Barbara L, Chao Moses V, Lee Francis S

Abstract excerpt

Neurogenesis, the division, migration, and differentiation of new neurons, occurs throughout life. Brain derived neurotrophic factor (BDNF) has been identified as a potential signaling molecule regulating neurogenesis in the subventricular zone (SVZ), but its functional consequences in vivo have not been well defined. We report marked and unexpected deficits in survival but not proliferation of newly born cells...

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Identifiers

PMID: 18322085
DOI: 10.1523/JNEUROSCI.4387-07.2008
PMCID: PMC2679965

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination.PMID 18322085Read ↗

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Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons.Semantic proximity Read ↗

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Brain-derived neurotrophic factor (Val66Met) polymorphism and olfactory ability in young adults.Semantic proximity Read ↗

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BDNF variant linked to anxiety-related behaviors.Semantic proximity Read ↗

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Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism contributes to developmental and estrous stage-specific expression of anxiety-like behavior in female mice.Semantic proximity Read ↗

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