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Article

Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2016

Ieraci Alessandro, Madaio Alessandro I, Mallei Alessandra, Lee Francis S, Popoli Maurizio

Abstract excerpt

Several studies have shown that exercise improves cognitive functions and emotional behaviors. Positive effects of exercise have been associated with enhanced brain plasticity, adult hippocampal neurogenesis, and increased levels of brain-derived neurotrophic factor (BDNF). However, a substantial variability of individual response to exercise has been described, which may be accounted for by individual genetic...

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Identifiers

PMID: 27388329
DOI: 10.1038/npp.2016.120
PMCID: PMC5101555

Genes

BDNF
FNDC5
PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice.PMID 27388329Read ↗

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Sex and BDNF Val66Met polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice.Semantic proximity Read ↗

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Impaired fear memory in a rat model of the brain-derived neurotrophic factor Val66Met polymorphism is reversed by chronic exercise.Semantic proximity Read ↗

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