Brain-Derived neurotrophic factor Val66met is associated with sex-specific impairment of cognitive flexibility under stress: A reversal learning search strategy analysis in a rat model.

Abstract excerpt

Cognitive flexibility is a core executive function vital for adaptation and adjustment to new information. The brain-derived neurotrophic factor (BDNF) single nucleotide polymorphism, val66met, has been suggested to modulate cognitive flexibility but it remains unclear how confounding variables such as stress and sex influence this relationship. Environmental enrichment (EE) may protect against stress-induced...

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