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Sex and BDNF Val66Met polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice.

Hormones and behavior - 1 Feb 2023

Islas-Preciado Dannia, Splinter Tallinn F L, Ibrahim Muna, Black Natasha, Wong Sarah, Lieblich Stephanie E, Liu-Ambrose Teresa, Barha Cindy K, Galea Liisa A M

Abstract excerpt

Females show greater benefits of exercise on cognition in both humans and rodents, which may be related to brain-derived neurotrophic factor (BDNF). A single nucleotide polymorphism (SNP), the Val66Met polymorphism, within the human BDNF gene, causes impaired activity-dependent secretion of neuronal BDNF and impairments to some forms of memory. We evaluated whether sex and BDNF genotype (Val66Met polymorphism...

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Identifiers

PMID: 36623432
DOI: 10.1016/j.yhbeh.2022.105297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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