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Article

Differences in genome-wide repeat sequence instability conferred by proofreading and mismatch repair defects.

Nucleic acids research - 30 Apr 2015

Lujan Scott A, Clark Alan B, Kunkel Thomas A

Abstract excerpt

Mutation rates are used to calibrate molecular clocks and to link genetic variants with human disease. However, mutation rates are not uniform across each eukaryotic genome. Rates for insertion/deletion (indel) mutations have been found to vary widely when examined in vitro and at specific loci in vivo. Here, we report the genome-wide rates of formation and repair of indels made during replication of yeast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25824945
DOI: 10.1093/nar/gkv271
PMCID: PMC4417177

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