Article
Distinct mutational behaviors differentiate short tandem repeats from microsatellites in the human genome.
Genome biology and evolution - 1 Jan 2013
Ananda Guruprasad, Walsh Erin, Jacob Kimberly D, Krasilnikova Maria, Eckert Kristin A, Chiaromonte Francesca, Makova Kateryna D
Abstract excerpt
A tandem repeat's (TR) propensity to mutate increases with repeat number, and can become very pronounced beyond a critical boundary, transforming it into a microsatellite (MS). However, a clear understanding of the mutational behavior of different TR classes and motifs and related mechanisms is lacking, as is a consensus on the existence of a boundary separating short TRs (STRs) from MSs. This hinders our...
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