Article

Inherent instability of simple DNA repeats shapes an evolutionarily stable distribution of repeat lengths

2025-01-10

Abstract excerpt

Using the Telomere-to-Telomere reference, we assembled the distribution of simple repeat lengths present in the human genome. Analyzing over two hundred mammalian genomes, we found remarkable consistency in the shape of the distribution across evolutionary epochs. All observed genomes harbor an excess of long repeats, which are potentially prone to developing into repeat expansion disorders. We measured mutation r...

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Literature Corpus work: ece88aab-70e6-5a4c-9d6d-e61041be0d80
DOI: 10.1101/2025.01.09.631797

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