Article
DNA polymerase stalling at structured DNA constrains the expansion of short tandem repeats.
Genome biology - 21 Aug 2020
Murat Pierre, Guilbaud Guillaume, Sale Julian E
Abstract excerpt
BACKGROUND: Short tandem repeats (STRs) contribute significantly to de novo mutagenesis, driving phenotypic diversity and genetic disease. Although highly diverse, their repetitive sequences induce DNA polymerase slippage and stalling, leading to length and sequence variation. However, current studies of DNA synthesis through STRs are restricted to a handful of selected sequences, limiting our broader...
Topics
- Base Sequence
- DNA
- DNA Replication
- DNA-Directed DNA Polymerase
- Evolution, Molecular
- Genetic Techniques
- Genome, Human
- Humans
- Kinetics
- Microsatellite Repeats
- Mutagenesis
- Mutation
- Point Mutation