Article
Microsatellite interruptions stabilize primate genomes and exist as population-specific single nucleotide polymorphisms within individual human genomes.
PLoS genetics - 1 Jul 2014
Ananda Guruprasad, Hile Suzanne E, Breski Amanda, Wang Yanli, Kelkar Yogeshwar, Makova Kateryna D, Eckert Kristin A
Abstract excerpt
Interruptions of microsatellite sequences impact genome evolution and can alter disease manifestation. However, human polymorphism levels at interrupted microsatellites (iMSs) are not known at a genome-wide scale, and the pathways for gaining interruptions are poorly understood. Using the 1000 Genomes Phase-1 variant call set, we interrogated mono-, di-, tri-, and tetranucleotide repeats up to 10 units in length....
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