Article

Systematic In Silico Off-Target Assessment of siRNAs: Integrated Tissue-Specific Scoring and Cross-Species Preclinical Model Selection with TargetSureR

2026-05-31

Abstract excerpt

Small interfering RNAs (siRNAs) have become a transformative class of nucleic acid therapeutics for clinical disease treatment, yet sequence-dependent off-target silencing continues to pose a major safety barrier that hinders their preclinical refinement and large-scale translational application. Existing bioinformatics tools only support partial off-target evaluation, either focusing on basic sequence optimizatio...

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Literature Corpus work: a23fccc2-e2c1-5b49-be8f-8331efdaa40f
DOI: 10.64898/2026.05.28.728477

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