Article

siRNADesign: A Graph Neural Network for siRNA Efficacy Prediction via Deep RNA Sequence Analysis

2024-04-30

Abstract excerpt

The clinical adoption of small interfering RNAs (siRNAs) has prompted the development of various computational strategies for siRNA design, from traditional data analysis to advanced machine learning techniques. However, previous studies have inadequately considered the full complexity of the siRNA silencing mechanism, neglecting critical elements such as siRNA positioning on mRNA, RNA base-pairing probabilities,...

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Literature Corpus work: 5ed78c58-d5d5-5fde-a473-7079619df607
DOI: 10.1101/2024.04.28.591509

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