Article

Biochemistry-informed design selects potent siRNAs against SARS-CoV-2

2022-12-09

Abstract excerpt

<h4>ABSTRACT</h4> RNA interference (RNAi) offers an efficient way to repress genes of interest, and it is widely used in research settings. Clinical applications emerged more recently, with 5 approved siRNAs (the RNA guides of the RNAi effector complex) against human diseases. The development of siRNAs against the SARS-CoV-2 virus could therefore provide the basis of novel COVID-19 treatments, while being easily...

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Literature Corpus work: ef700a8d-c2db-5cb5-9201-def7720326d7
DOI: 10.1101/2022.12.08.519651

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