Article

SPOROS: A pipeline to analyze DISE/6mer seed toxicity

2021-07-02

Abstract excerpt

<h4>ABSTRACT</h4> micro(mi)RNAs are (18-22nt long) noncoding short (s)RNAs that suppress gene expression by targeting the 3’ untranslated region of target mRNAs. This occurs through the seed sequence located in position 2-7/8 of the miRNA guide strand, once it is loaded into the RNA induced silencing complex (RISC). G-rich 6mer seed sequences can kill cells by targeting C-rich 6mer seed matches located in genes t...

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Literature Corpus work: d8aa2d6f-1301-5f1f-b0ac-65f37e62a466
DOI: 10.1101/2021.07.01.450720

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