Article

Rethinking modRNA Immunogenicity: Toward a Human Genotype-Guided PRR/ISR Atlas

2026-05-09

Abstract excerpt

In vitro-transcribed modified mRNA is a promising platform for transient protein replacement in regenerative medicine, including cardiomyocyte regeneration, but repeated dosing is limited by variable innate immune activation and ISR-mediated translation shutdown across individuals. We propose a Human-specific PRR/ISR Immunogenicity Atlas: a focused, genotype-aware computational framework linking patient genetic va...

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Literature Corpus work: a94acff1-cac8-5177-8ddb-7f29804e9d18
DOI: 10.20944/preprints202605.0581.v1

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