Article

Pervasive Transcriptome Interactions of Protein-Targeted Drugs

2022-07-20

Abstract excerpt

The off-target toxicity of drugs targeted to proteins imparts substantial health and economic costs. Proteome interaction studies can reveal off-target effects with unintended proteins; however, little attention has been paid to intracellular RNAs as potential off targets that may contribute to toxicity. To begin to assess this, we developed a reactivity-based RNA profiling (RBRP) methodology, and applied it to un...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 11806d77-e627-5909-9ca0-687df5633001
DOI: 10.1101/2022.07.18.500496

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pervasive Transcriptome Interactions of Protein-Targeted DrugsDOI 10.1101/2022.07.18.500496Read

SHIFTR enables the unbiased and multiplexed identification of proteins bound to specific RNA regions in live cellsSemantic proximity Read

Longitudinal and large-scale monitoring of transcriptome and RBP-RNA interactome in living cells by engineered protein nanocagesSemantic proximity Read

From Traditional Biomarkers to Transcriptome Analysis in Drug DevelopmentSemantic proximity Read

Live-Cell Covalent Profiling Reveals Principles of RNA-Small Molecule Recognition across the Human TranscriptomeSemantic proximity Read

A Proteomic Platform to Identify Off-Target Proteins Associated with Therapeutic Modalities that Induce Protein Degradation or Gene SilencingSemantic proximity Read

Longitudinal and large-scale monitoring of transcriptome and RBP-RNA interactome in living cells by engineered protein nanocagesSemantic proximity Read

Predicting inhibitory and activatory drug targets by chemically and genetically perturbed transcriptome signaturesSemantic proximity Read

A Proteomic Platform to Identify Off-Target Proteins Associated with Therapeutic Modalities that Induce Protein Degradation or Gene SilencingSemantic proximity Read

From single-omics to interactomics: How can ligand-induced perturbations modulate single-cell phenotypes?Semantic proximity Read

Transcriptome-wide mapping of small-molecule RNA-binding sites in live cellsSemantic proximity Read

Transcriptome-wide mapping reveals an RNA-dependent mechanism of platinum cancer drugsSemantic proximity Read

Predicting protein targets for drug-like compounds using transcriptomicsSemantic proximity Read