Article

SIREN: Suite for Intelligent RNAi Design and Evaluation of Nucleotide Sequences

2025-05-30

Abstract excerpt

<h4>Motivation</h4> RNA interference (RNAi) is a powerful tool for gene silencing across biological research, therapeutics, and agriculture. While siRNA design has benefited from advances in thermodynamic modeling and machine learning, comprehensive tools for designing long double-stranded RNAs (dsRNAs) with minimized off-target effects remain limited. <h4>Results</h4> Here, we present SIREN, an open-source Pyth...

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Literature Corpus work: df0b2a57-c018-5ab1-948d-46523c3d2876
DOI: 10.1101/2025.05.26.656188

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