Article

miRNA Mimic Optimization: Chemical Structure – Activity – Targetome Relationship to Engineer Selective Anti-Tumor Immunity in T cells

2025-04-21

Abstract excerpt

MicroRNA (miRNA) mimic therapies act through a broad and complex targetome in disease contexts. However, both the composition of these targetomes and the impact of chemical modifications on them remain poorly understood. In this study, we investigate eight fully chemically modified miRNA scaffolds across three miRNA sequences in a model immune disorder, graft-versus-host-disease (GvHD), which is an off-tumor effec...

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Literature Corpus work: e4bce6eb-5665-5f38-a805-e8c098cfeedd
DOI: 10.1101/2025.04.16.649059

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