Article

eSkip2 prioritizes exon-skipping antisense oligonucleotide target regions across exon–intron contexts

2026-05-11

Abstract excerpt

Antisense oligonucleotides (ASOs) for exon skipping are increasingly used to correct pathogenic splicing; however, rational target-region selection remains difficult because regulatory information is distributed across exons, introns, and splice junctions. Here we present eSkip2, a framework for prioritizing exon-skipping ASO target regions from joint exon–intron sequence context. eSkip2 combines transfer learning...

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Literature Corpus work: 8a7b0a52-c609-5596-a9b2-047e8d1471cf
DOI: 10.64898/2026.05.05.722571

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