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Article

Human disease-associated single nucleotide polymorphism changes the orientation of DROSHA on pri-mir-146a.

RNA (New York, N.Y.) - 1 Dec 2020

Le Cong Truc, Nguyen Thuy Linh, Nguyen Trung Duc, Nguyen Tuan Anh

Abstract excerpt

The Microprocessor complex of DROSHA and DGCR8 initiates the biosynthesis of microRNAs (miRNAs) by processing primary miRNAs (pri-miRNAs). The Microprocessor can be oriented on pri-miRNAs in opposite directions to generate productive and unproductive cleavages at their basal and apical junctions, respectively. However, only the productive cleavage gives rise to miRNAs. A single nucleotide polymorphism (SNP,...

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Identifiers

PMID: 32994184
DOI: 10.1261/rna.077487.120
PMCID: PMC7668254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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