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Article

Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing.

Nucleic acids research - 1 Jan 2006

Yeom Kyu-Hyeon, Lee Yoontae, Han Jinju, Suh Mi Ra, Kim V Narry

Abstract excerpt

DGCR8/Pasha is an essential cofactor for Drosha, a nuclear RNase III that cleaves the local hairpin structures embedded in long primary microRNA transcripts (pri-miRNAs) in eukaryotes. Although our knowledge of pri-miRNA processing has significantly advanced in recent years, the precise role of DGCR8 in this pathway remains unclear. In our present study, we dissect the domains in DGCR8 that contribute to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Structure, Tertiary

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Source

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Identifiers

PMID: 16963499
DOI: 10.1093/nar/gkl458
PMCID: PMC1636349

Genes

DGCR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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