Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptomic heterogeneity of non-beta islet cells is associated with type 2 diabetes development in mouse models

7 Nov 2024

Abstract excerpt

Abstract Aims/hypothesis The aim of this work was to understand the role of non-beta cells in pancreatic islets at early stages of type 2 diabetes pathogenesis. Methods Specific clustering was employed to single-cell transcriptome data from islet cells of obese mouse strains differing in their diabetes susceptibility (diabetes-resistant B6.V.Lepob/ob [OB] and diabetes-susceptible New Zealand Obese [NZO] mice) on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Diabetes and associated disorders
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39508880
DOI: 10.1007/s00125-024-06301-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic heterogeneity of non-beta islet cells is associated with type 2 diabetes development in mouse modelsPMID 39508880Read ↗

The single-cell RNA sequencing (scRNA-seq) transcriptome profile of pancreatic islets in three types of diabetic mice and its pathological changesSemantic proximity Read ↗

Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlasSemantic proximity Read ↗

Transcriptome analysis of islets from diabetes‐resistant and diabetes‐prone obese mice reveals novel gene regulatory networks involved in beta‐cell compensation and failureSemantic proximity Read ↗

Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlasSemantic proximity Read ↗

RNA-Seq Analysis of Islets to Characterise the Dedifferentiation in Type 2 Diabetes Model Mice db/dbSemantic proximity Read ↗

Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes.Semantic proximity Read ↗

Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases.Semantic proximity Read ↗

Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases.Semantic proximity Read ↗

Interactions between islet-resident macrophages and β cells in diabetesSemantic proximity Read ↗

Differential transcriptome analysis of diabetes-resistant and -sensitive mouse islets reveals significant overlap with human diabetes susceptibility genes.Semantic proximity Read ↗

Identification of unique cell type responses in pancreatic islets to stressSemantic proximity Read ↗

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 DiabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.