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IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes

23 Sept 2021

Abstract excerpt

AIMS/HYPOTHESIS: Type 2 diabetes is characterised by islet amyloid and toxic oligomers of islet amyloid polypeptide (IAPP). We posed the questions, (1) does IAPP toxicity induce an islet response comparable to that in humans with type 2 diabetes, and if so, (2) what are the key transcriptional drivers of this response? METHODS: The islet transcriptome was evaluated in five groups of mice: beta cell specific...

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PMID: 34554282
DOI: 10.1007/s00125-021-05569-2

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