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Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetes

2025-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Both alpha and beta cells are dysfunctional in type 1 diabetes (T1D), but beta cells die while alpha cells survive the immune attack. Understanding the mechanisms underlying alpha-cell resistance could identify new approaches to protect beta cells. Herein, we analysed single-cell datasets from human alpha and beta cells under basal/unstimulated conditions and under immune-mediated stress. Alpha...

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Literature Corpus work
9cc00d6a-71de-513d-b165-55130c3b9553
DOI
10.1101/2025.07.26.666935
Open publication

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Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetesDOI 10.1101/2025.07.26.666935
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