Article

Calorie Restriction Upregulates Islet PD-L1 Signaling and Decreases the Risk of Auto-immune Diabetes Onset in NOD Mice

2026-02-17

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease where beta cells are destroyed by cytotoxic T cells. Calorie restriction (CR) enhances glucose homeostasis and promotes beta cell longevity and was used as therapeutic strategy for T1D prior to the discovery of insulin. However, a significant knowledge gap remains regarding its effects on beta cells during the pathogenesis of autoimmunity. We demonstrate that CR enhan...

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Literature Corpus work: 56e974b3-81ae-5f8e-9f30-0a15802e43c8
DOI: 10.64898/2026.02.15.705935

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