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An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

22 May 2020

Abstract excerpt

Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. We presently characterize human beta cell responses to IFNα by combining ATAC-seq, RNA-seq and proteomics assays. The initial response to IFNα is characterized by chromatin remodeling, followed by...

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PMID: 32444635
DOI: 10.1038/s41467-020-16327-0

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