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Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress

5 Oct 2022

Abstract excerpt

Pancreatic islet beta cells are essential for maintaining glucose homeostasis. To understand the impact of aging on beta cells, we performed meta-analysis of single-cell RNA sequencing datasets, transcription factor (TF) regulon analysis, high-resolution confocal microscopy, and measured insulin secretion from nondiabetic donors spanning most of the human life span. This revealed the range of molecular and...

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PMID: 36197983
DOI: 10.1126/sciadv.abo3932

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