Article

Lifestyle intervention is associated with attenuation of ER stress/inflammation and enhancement of naive immune cell identity in older adults with metabolic disease

2026-05-12

Abstract excerpt

Chronic inflammation and cellular stress are hallmarks of aging, obesity, and type 2 diabetes (T2D), but whether these programs can be modulated by lifestyle intervention in late life, particularly in the presence of established metabolic disease, remain unknown. We profiled circulating immune cells from older adults with obesity and T2D (ages 66–83 years; n = 9) before and after a 6-month lifestyle intervention...

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Literature Corpus work: d749a06a-03ad-5dc9-8f7c-b1aa99209527
DOI: 10.64898/2026.05.08.723786

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