Article

Ancestry-specific gene expression in peripheral monocytes mediates risk of neurodegenerative disease

2024-11-22

Abstract excerpt

It is hypothesised that peripheral immune states responding to regional environmental triggers contribute to central neurodegeneration. Region-specific genetic selection pressures require this hypothesis to be assessed in an ancestry specific manner. Here we utilise genome-wide association studies and expression quantitative trait loci from African, East Asian and European ancestries to show that genes causing neu...

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Literature Corpus work: a20cafdd-de31-51eb-ab89-51e8cca2a6db
DOI: 10.1101/2024.11.20.624489

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