Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.

doi:10.1126/science.1249547

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Article

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.

Science (New York, N.Y.) - 2 May 2014

Raj Towfique, Rothamel Katie, Mostafavi Sara, Ye Chun, Lee Mark N, Replogle Joseph M, Feng Ting, Lee Michelle, Asinovski Natasha, Frohlich Irene, Imboywa Selina, Von Korff Alina, Okada Yukinori, Patsopoulos Nikolaos A, Davis Scott, McCabe Cristin, Paik Hyun-il, Srivastava Gyan P, Raychaudhuri Soumya, Hafler David A, Koller Daphne, Regev Aviv, Hacohen Nir, Mathis Diane, Benoist Christophe, Stranger Barbara E, De Jager Philip L

Abstract excerpt

To extend our understanding of the genetic basis of human immune function and dysfunction, we performed an expression quantitative trait locus (eQTL) study of purified CD4(+) T cells and monocytes, representing adaptive and innate immunity, in a multi-ethnic cohort of 461 healthy individuals. Context-specific cis- and trans-eQTLs were identified, and cross-population mapping allowed, in some cases, putative...

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Identifiers

PMID: 24786080
DOI: 10.1126/science.1249547
PMCID: PMC4910825

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Source receipt: pubmed, retrieved 7 Sept 2026.

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