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Article

Population and single-cell analyses reveal immune cell-specific expression profiles associated with Alzheimer's disease risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2026

Lindbohm Joni V, Stražar Martin, Lee Hang-Mao, Ashenberg Orr, Mars Nina, Sipilä Pyry N, Ripatti Samuli, Graham Dan, Kivimäki Mika, Xavier Ramnik J

Abstract excerpt

INTRODUCTION: Dysregulation of the peripheral immune system may increase Alzheimer's disease (AD) risk, but the underlying cell type-specific mechanisms remain unclear. METHODS: We conducted Mendelian randomization and colocalization analyses of 4489 genes using single-cell expression quantitative trait locus data from unstimulated and stimulated peripheral immune cells, integrated with an AD genome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41866337
DOI: 10.1002/alz.71282
PMCID: PMC13093567

Genes

FIBP
PLEKHA1
TSTD1
BIN1
CTSH
CTSW
EPHA1
FCER1G
KAT8
SCIMP
STX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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