Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways.

doi:10.1002/alz.70377

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Article

Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2025

Bradley Joseph, Pottier Cyril, da Fonseca Eder Lucio, Kurup Jiji Thulaseedhara, Western Daniel, Wang Ciyang, Neupane Achal, Ray Nicholas R, Jean-Francois Melissa, Ali Muhammad, Timsina Jigyasha, Bergmann Kristy, Budde John, Martin Eden R, Pericak-Vance Margaret A, Cuccaro Michael, Naj Adam C, Kunkle Brian W, Schellenberg Gerard D, Fernandez Victoria, Haines Jonathan, Morris John C, Holtzman David M, Perrin Richard J, Reitz Christiane, Beecham Gary W, Cruchaga Carlos

Abstract excerpt

INTRODUCTION: Most genetic studies for Alzheimer's disease (AD) have been focused on late-onset AD (LOAD). There are no large genetic studies on early-onset AD (EOAD). METHODS: We performed a multi-ancestry (non-Hispanic European, African, and East Asian) genome-wide association study (GWAS) including a total of 7,349 cases and 17,887 control. Cases with age at onset younger than 70 years were included....

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PMID: 40556318
DOI: 10.1002/alz.70377
PMCID: PMC12187977

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