Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways

Abstract excerpt

<title>Abstract</title> <p>Alzheimer Disease (AD) is a highly polygenic disease that presents with relatively earlier onset (≤70yo; EOAD) in about 5% of cases. Around 90% of these EOAD cases remain unexplained by pathogenic mutations. Using data from EOAD cases and controls, we performed a genome-wide association study (GWAS) and trans-ancestry meta-analysis on non-Hispanic Whites (NHW, NCase=6,282, NControl=13,3...

Topics

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• Age of Onset
• Aged
• Alzheimer Disease
• Genome-Wide Association Study
• Glutamic Acid
• Polymorphism, Single Nucleotide
• Quantitative Trait Loci
• Signal Transduction

Identifiers and source

Literature Corpus work

06b97787-0aa9-5c38-8747-48d2836bfe57

DOI

10.21203/rs.3.rs-4480585/v1