Article

Functional dissection of TADs reveals non-essential and instructive roles in regulating gene expression

2019-03-05

Abstract excerpt

The genome is organized in megabase-sized three-dimensional units, called Topologically Associated Domains (TADs), that are separated by boundaries. TADs bring distant cis-regulatory elements into proximity, a process dependent on the cooperative action of cohesin and the DNA binding factor CTCF. Surprisingly, genome-wide depletion of CTCF has little effect on transcription, yet structural variations affecting TAD...

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Literature Corpus work: a200f491-7efb-5a94-a566-c2b2f18f6e8f
DOI: 10.1101/566562

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