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Article

Long-range control of gene expression: emerging mechanisms and disruption in disease.

American journal of human genetics - 1 Jan 2005

Kleinjan Dirk A, van Heyningen Veronica

Abstract excerpt

Transcriptional control is a major mechanism for regulating gene expression. The complex machinery required to effect this control is still emerging from functional and evolutionary analysis of genomic architecture. In addition to the promoter, many other regulatory elements are required for spatiotemporally and quantitatively correct gene expression. Enhancer and repressor elements may reside in introns or up-...

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PMID: 15549674
DOI: 10.1086/426833
PMCID: PMC1196435

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