Article
Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.
Nature cell biology - 1 Aug 2017
Hanssen Lars L P, Kassouf Mira T, Oudelaar A Marieke, Biggs Daniel, Preece Chris, Downes Damien J, Gosden Matthew, Sharpe Jacqueline A, Sloane-Stanley Jacqueline A, Hughes Jim R, Davies Benjamin, Higgs Douglas R
Abstract excerpt
The genome is organized via CTCF-cohesin-binding sites, which partition chromosomes into 1-5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, containing the mouse α-globin gene cluster, lying within a ∼1 Mb TAD. We find that the sub-TAD is flanked by predominantly convergent CTCF-cohesin sites that are ubiquitously...
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