Article
Formation of new chromatin domains determines pathogenicity of genomic duplications.
Nature - 13 Oct 2016
Franke Martin, Ibrahim Daniel M, Andrey Guillaume, Schwarzer Wibke, Heinrich Verena, Schöpflin Robert, Kraft Katerina, Kempfer Rieke, Jerković Ivana, Chan Wing-Lee, Spielmann Malte, Timmermann Bernd, Wittler Lars, Kurth Ingo, Cambiaso Paola, Zuffardi Orsetta, Houge Gunnar, Lambie Lindsay, Brancati Francesco, Pombo Ana, Vingron Martin, Spitz Francois, Mundlos Stefan
Abstract excerpt
Chromosome conformation capture methods have identified subchromosomal structures of higher-order chromatin interactions called topologically associated domains (TADs) that are separated from each other by boundary regions. By subdividing the genome into discrete regulatory units, TADs restrict the contacts that enhancers establish with their target genes. However, the mechanisms that underlie partitioning of the...
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